Punks and Nerds

 There are a lot of really funny webcomics, but my personal favorite has to be Punks and Nerds. It emphasizes much more on the "nerds" part of the title, with references out the ass, and has running back-stories about Doug Funnie and Mario & Princess Peach. It also has a talking dildo and and a superhero named Bruceman. But don't take my word for it, check it out right here:
The Punks and Nerds Webcomic